Can I get an additional Rs 50,000 tax benefit if I opt for NPS if my 80C is already filled with PF, FD and home loan?

Yes, if you have exhausted the Section 80C limit of Rs 1,50,000, then consider investing in NPS. Deduction for self-contribution to NPS - section 80CCD (1b) has been introduced for an additional deduction of up to Rs 50,000 for the amount deposited by a taxpayer to their NPS account.